Methyl iodide → (5-Bromo-6-hydroxy-pyridin-3-yl)-acetic acid ethyl ester
반응식
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6]1[CH:7]=[N:8][C:9]([O:13]C)=[C:10]([Br:12])[CH:11]=1)[CH3:2].IC>C(Cl)(Cl)Cl.C(=O)([O-])[O-].[Ag+2]>[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6]1[CH:7]=[N:8][C:9]([OH:13])=[C:10]([Br:12])[CH:11]=1)[CH3:2]참가 물질
5
반응 조건
- 온도
- 55 °C
실험 절차
(5-Bromo-6-methoxy-pyridin-3-yl)-acetic acid ethyl ester (5.02 mmol) was dissolved in CHCl3 (17 mL). Silver carbonate (1.58 g, 5.7 mmol) and iodomethane (0.82 mL, 13.14 mmol) were added, and the reaction was stirred at 55° C. for 2.5 hours. The mixture was filtered through Celite, and the filtrate was concentrated and purified by silica gel chromatography (0-60% EtOAc in hexanes) to give (5-bromo-6-hydroxy-pyridin-3-yl)-acetic acid ethyl ester.
후처리
- filtrationThe mixture was filtered through Celite
- concentrationthe filtrate was concentrated
- custompurified by silica gel chromatography (0-60% EtOAc in hexanes)
출처 및 근거
- ORD 기록
- ord-7448f2e808114f2abd30cf986c23124b
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08049015B2
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