Hydrochloric Acid → HCID 45117461, 화합물

HRID 555324노트

반응식

HRID 555324 반응식
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][C:16]1=[O:25])=O)(C)(C)C.Cl.[OH-].[Na+]>C(OCC)C.O>[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][C:16]1=[O:25]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66987879HCID 66987879, 화합물

생성물 1

HCID 45117461HCID 45117461, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

1-[6-(N-tert-Butoxycarbonylamino)-1-hexyl]-1,2-dihydroquinoline-2-one (480 mg) was treated with a large excess of hydrogen chloride in dietyl ether with stirring for 1 hour at room temperature. The crystalline product was isolated by filtration and redissolved in water whereafter the solution was made strongly alkaline with sodium hydroxide and extracted twice with chloroform. The organic phase was dried over potassium carbonate, filtered and evaporated to yield the title compound as a colourless oil.

후처리

  1. customThe crystalline product was isolated by filtration
  2. extractionextracted twice with chloroform
  3. dry with materialThe organic phase was dried over potassium carbonate
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-cf6bfbedb1b941a1a6c920199ba03243
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08053446B2

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