Acetyl chloride → 4-Phenyl-2-pyridinecarbonitrile
반응식
[C:1]1([C:7]2[CH:12]=[CH:11][N+:10]([O-])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[Si]([C:18]#[N:19])(C)C.C(Cl)(=O)C.C([O-])([O-])=O.[Na+].[Na+]>C(Cl)Cl>[C:1]1([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([C:18]#[N:19])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1참가 물질
6
실험 절차
To a solution of 4-phenylpyridine N-oxide (5 g) in DCM (50 mL) was added at RT trimethylsilylcyanide (11 mL), followed by acetyl chloride (3.1 mL) over 10 min. The reaction mixture was stirred overnight at RT. A solution of aq. 10% Na2CO3 was added and the mixture was extracted with EA. The combined org. phases were washed with brine, dried (Na2SO4) and evaporated off. Filtration over a plug of silica gel (Hept/EA 1/1) gave the desired compound (450 mg).
후처리
- extractionthe mixture was extracted with EA
- washphases were washed with brine
- dry with materialdried (Na2SO4)
- customevaporated off
- filtrationFiltration over a plug of silica gel (Hept/EA 1/1)
출처 및 근거
- ORD 기록
- ord-9c430b76a63140548e31507170d80bec
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08058263B2
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