Propionyl chloride → 2-Ethyl-1-phenyl-1H-quinazolin-4-one

HRID 557120

반응식

HRID 557120 반응식
[C:1]1([NH:7][C:8]2[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=2[C:10]([NH2:12])=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:17](Cl)(=O)[CH2:18][CH3:19].C(=O)(O)[O-].[Na+]>ClC(Cl)Cl>[CH2:18]([C:19]1[N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]2[C:9]([C:10](=[O:11])[N:12]=1)=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH3:17]

참가 물질

5

반응물 3

HCID 62324Propionyl chlorideHCID 964552-(Phenylamino)BenzamideHCID 516892Sodium Bicarbonate

생성물 1

HCID 669910272-Ethyl-1-phenyl-1H-quinazolin-4-one

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
0 °C

실험 절차

2.0 g (9.42 mmol) 2-phenylamino-benzamide were dissolved in 30 ml trichloromethane the solution was cooled to 0° C., and 2.61 g (2.44 ml, 28.2 mmol) propionyl chloride was added slowly. The mixture was boiled for 90 minutes and afterwards neutralized with a saturated sodium bicarbonate solution. After evaporation the substance was crystallized from isopropanol.

후처리

  1. customAfter evaporation the substance
  2. customwas crystallized from isopropanol

출처 및 근거

ORD 기록
ord-3a03597141834694b183180e548982e9
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058431B2

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