Sodium Hydroxide → 6-fluoro-2,3-dihydro-1H-indole
반응식
C([BH3-])#N.[Na+].[F:5][C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[CH:11][NH:12]2)=[CH:8][CH:7]=1.[OH-].[Na+]>C(O)(=O)C>[F:5][C:6]1[CH:14]=[C:13]2[C:9]([CH2:10][CH2:11][NH:12]2)=[CH:8][CH:7]=1참가 물질
5
실험 절차
Add sodium cyanoborohydride (5.57 g, 88.78 mmol) to a solution of 6-fluoro-indole (10 g, 73.99 mmol) in acetic acid (100 ml). Stir at room temperature for 30 minutes. Pour the reaction mixture into 5N sodium hydroxide and extract with ethyl acetate. Wash the combined organic phases with saturated aqueous sodium bicarbonate followed by saturated aqueous sodium chloride. Concentrated under reduced pressure and subject the residue to silica gel chromatography to provide the desired compound as a colorless oil (7.69 g, 76%).
후처리
- extractionextract with ethyl acetate
- washWash the combined organic phases with saturated aqueous sodium bicarbonate
- concentrationConcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-5876ebfc213c4646997de813d5d3e5d2
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08058425B2
반응 노트
불러오는 중…