Hydroxyamine hydrochloride → Methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate

HRID 557615

반응식

HRID 557615 반응식
[CH3:1][O:2][C:3](=[O:17])[CH:4]([C:8](=[O:16])[C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][CH:10]=1)[C:5](=O)[CH3:6].Cl.[NH2:19]O>C(O)(=O)C>[CH3:1][O:2][C:3]([C:4]1[C:5]([CH3:6])=[N:19][O:16][C:8]=1[C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][CH:10]=1)=[O:17]

참가 물질

4

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 603116Methyl acetyl(p-bromobenzoyl)acetate

생성물 1

HCID 56604575Methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
115 °C

실험 절차

2-(4-Bromo-benzoyl)-3-oxo-butyric acid methyl ester (11 g, 39 mmol) and hydroxylamine hydrochloride (2.66 g, 39 mmol) were combined in acetic acid (50 mL), and the reaction was stirred at 115° C. for 1 hour. After cooling, aqueous work-up gave the title compound.

후처리

  1. temperatureAfter cooling

출처 및 근거

ORD 기록
ord-0e484f1de3224db0916b7d72db495d28
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058300B2

연결된 노트

불러오는 중…