Hydrochloric Acid → 4'-(1-(Isopropoxycarbonyl)cyclopropyl)biphenyl-4-carboxylic acid

HRID 557627노트

반응식

HRID 557627 반응식
[CH:1]([O:4][C:5]([C:7]1([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([C:22](=[O:24])C)=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2].BrBr.[OH-].[Na+].Cl.S(S([O-])=O)([O-])(=O)=[O:31].[Na+].[Na+]>O1CCOCC1.O>[CH:1]([O:4][C:5]([C:7]1([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([OH:31])=[O:24])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:9][CH2:8]1)=[O:6])([CH3:2])[CH3:3]

참가 물질

8

반응물 5

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 24408Bromine2회HCID 656671Sodium PyrosulfiteHCID 666602881-(4'-Acetylbiphenyl-4-yl)cyclopropanecarboxylic acid isopropyl ester

생성물 1

HCID 666604224'-(1-(Isopropoxycarbonyl)cyclopropyl)biphenyl-4-carboxylic acid

시약·촉매·용매 2

HCID 962Water용매2회HCID 312751,4-Dioxane용매

실험 절차

To 1-(4′-acetylbiphenyl-4-yl)cyclopropanecarboxylic acid isopropyl ester (11.6 g, 36 mmol) in dioxane (200 mL) at ˜10° C. was added a solution of bromine (28.8 g, 180 mmol), sodium hydroxide (24.5 g, 612 mmol) in water (150 mL). The solution was stirred at room temperature for 30 minutes poured into water (500 mL) and acidified with dilute hydrochloric acid. Sodium metabisulfite was added until the brown bromine color dissipated. The product was filtered and dried in a vacuum over overnight at 40° C. to yield 10 g of the title compound.

후처리

  1. filtrationThe product was filtered
  2. customdried in a vacuum over overnight at 40° C.

출처 및 근거

ORD 기록
ord-b5e02b4f28314d53a065d350aa938215
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058300B2

반응 노트

불러오는 중…