1,2-Dichloroethane → Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride

HRID 55772

반응식

HRID 55772 반응식
[F:1][C:2]1[C:7]([OH:8])=[C:6]([F:9])[C:5]([F:10])=[C:4]([F:11])[C:3]=1[F:12].C(Cl)C[Cl:15].Cl.[N:18]12[CH2:25][CH2:24][CH:21]([CH2:22][CH2:23]1)[CH:20]([CH2:26][C:27](O)=[O:28])[CH2:19]2>C(N(CC)C(C)C)(C)C.ClCCl>[ClH:15].[N:18]12[CH2:23][CH2:22][CH:21]([CH2:24][CH2:25]1)[CH:20]([CH2:26][C:27]([O:8][C:7]1[C:2]([F:1])=[C:3]([F:12])[C:4]([F:11])=[C:5]([F:10])[C:6]=1[F:9])=[O:28])[CH2:19]2

참가 물질

6

반응물 3

HCID 111,2-DichloroethaneHCID 13041PentafluorophenolHCID 230241472-(Quinuclidin-3-yl)acetic acid hydrochloride

생성물 1

HCID 86610796Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride

시약·촉매·용매 2

HCID 81531Diisopropylethylamine촉매HCID 6344Dichloromethane용매

실험 절차

358 mg (1.94 mmol) of pentafluorophenol, 120.5 mg (0.63 mmol) of EDC and 1 drop of N,N-diisopropylethylamine are added to a solution of 100 mg (0.49 mmol) of 1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride in 4 ml of dichloromethane at 0° C. The mixture is stirred at room temperature for 18 h. The contents of the flask are concentrated in vacuo and dried under high vacuum. The resulting crude product is employed without further purification in the following stages.

후처리

  1. concentrationThe contents of the flask are concentrated in vacuo
  2. customdried under high vacuum
  3. customThe resulting crude product is employed without further purification in the following stages

출처 및 근거

ORD 기록
ord-b3b1aaa0e07f4281b55d14c723e1b6a1
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09433614B2

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