1-Bromo-2-Chloroethane → 1-(4-Vinylphenyl)cyclopropanecarbonitrile
반응식
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]#[N:11])=[CH:5][CH:4]=1)=[CH2:2].Br[CH2:13][CH2:14]Cl>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.[OH-].[Na+].O>[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:10]#[N:11])[CH2:14][CH2:13]2)=[CH:5][CH:4]=1)=[CH2:2]참가 물질
6
반응 조건
- 온도
- 70 °C
실험 절차
A mixture of (4-vinylphenyl)acetonitrile (2.1 g, 0.015 mol), 1-bromo-2-chloro-ethane (1.4 mL, 0.016 mol) and benzyltriethylammonium chloride (0.2 g, 0.0008 mol) in aqueous sodium hydroxide solution (20m, 6 mL) was stirred at 70° C. for 1 h. The reaction mixture was cooled, diluted with water and extracted with ethyl ether. The combined ether layers were washed with water and brine, dried and concentrated to afford the product.
후처리
- temperatureThe reaction mixture was cooled
- extractionextracted with ethyl ether
- washThe combined ether layers were washed with water and brine
- customdried
- concentrationconcentrated
- customto afford the product
출처 및 근거
- ORD 기록
- ord-6f89eb4704a341899b0d4caa84791139
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08058288B2
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