Hydrochloric Acid → 4-chloro-1-methyl-1H-pyrrole-2-carboxylic acid
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([O:10]C)=[O:9])[N:5]([CH3:7])[CH:6]=1.[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([OH:10])=[O:9])[N:5]([CH3:7])[CH:6]=1참가 물질
5
실험 절차
To a solution of methyl 4-chloro-1-methyl-1H-pyrrole-2-carboxylate (130 mg, 0.75 mmol) in MeOH (4 mL), aq. 1N NaOH (3 mL) was added. After being stirred at room temperature overnight, the mixture was acidified with 1N HCl to pH 1-2. The product was extracted with EtOAc. The EtOAc phase was separated, dried over Na2SO4, concentrated in vacuo to give 4-chloro-1-methyl-1H-pyrrole-2-carboxylic acid as a solid (111 mg).
후처리
- extractionThe product was extracted with EtOAc
- customThe EtOAc phase was separated
- dry with materialdried over Na2SO4
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-60d6ba92453f4a41854fb508bf446237
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08063077B2
반응 노트
불러오는 중…