Benzylamine → Ethyl 3-(benzylamino)-3-methylbutanoate

HRID 561118

반응식

HRID 561118 반응식
[CH3:1][C:2]([CH3:9])=[CH:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH2:10]([NH2:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>CCO>[CH2:10]([NH:17][C:2]([CH3:9])([CH3:1])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 7504BenzylamineHCID 12516Ethyl 3,3-dimethylacrylate

생성물 1

HCID 288946Ethyl 3-(benzylamino)-3-methylbutanoate수율 21.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of ethyl 3,3-dimethylacrylate (19.3 g, 0.151 mol) in EtOH (150 mL) was added benzylamine (16.2 g, 0.151 mol) and refluxed for 24 h. The reaction mixture was concentrated in vacuo. The distillation of the residue gave ethyl 3-benzylamino-3-methylbutyrate as a colorless oil (7.48 g, 21%).

후처리

  1. temperaturerefluxed for 24 h
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. distillationThe distillation of the residue

출처 및 근거

ORD 기록
ord-319b932dd8ae4c888979a6e751abcd91
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063221B2

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