Pyrrole → 3-Fluoro-1-nitro-4-(1H-pyrrol-1-yl)benzene
반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[F:11].C([O-])([O-])=O.[K+].[K+].[NH:18]1[CH:22]=[CH:21][CH:20]=[CH:19]1>CS(C)=O.O>[F:11][C:3]1[CH:4]=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=1[N:18]1[CH:22]=[CH:21][CH:20]=[CH:19]1참가 물질
6
반응 조건
- 온도
- 90 °C
실험 절차
To a solution of 1,2-difluoro-4-nitrobenzene (1.59 g, 10 mmol) in DMSO (15 mL) were added K2CO3 (3.04 g, 22 mmol) and pyrrole (0.74 g, 11 mmol) with stirring. The reaction mixture was heated at 90° C. for 18 h, and cooled to rt. The mixture was diluted with water (50 mL), filtered and the filter cake was dried to give the title compound as a yellow solid (2.00 g, 97%).
후처리
- temperaturecooled to rt
- filtrationfiltered
- customthe filter cake was dried
출처 및 근거
- ORD 기록
- ord-d97e250c56b54b6ea7fde21ea169c008
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434695B2
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