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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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proline dl-form → 5-[(2,4-Dichlorophenyl){5-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione

HRID 561382
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HRID 561382 반응식
[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH3:11][C:12]1([CH3:20])[O:19][C:17](=[O:18])[CH2:16][C:14](=[O:15])[O:13]1.N1CCCC1C(O)=O.[F:29][C:30]1[CH:31]=[C:32]2[C:36](=[C:37]([CH2:39][S:40][CH3:41])[CH:38]=1)[NH:35][CH:34]=[CH:33]2>C(#N)C>[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[CH:4]([C:33]1[C:32]2[C:36](=[C:37]([CH2:39][S:40][CH3:41])[CH:38]=[C:30]([F:29])[CH:31]=2)[NH:35][CH:34]=1)[CH:16]1[C:17](=[O:18])[O:19][C:12]([CH3:20])([CH3:11])[O:13][C:14]1=[O:15]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 614proline dl-formHCID 134042,4-DichlorobenzaldehydeHCID 162492,2-Dimethyl-1,3-dioxane-4,6-dioneHCID 583922275-Fluoro-7-[(methylsulfanyl)methyl]-1H-indole

생성물 1

HCID 583923405-[(2,4-Dichlorophenyl){5-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione

시약·촉매·용매 1

HCID 6342
Acetonitrile
용매

실험 절차

0.81 g (4.60 mmol) of 2,4-dichlorobenzaldehyde, 0.66 g (4.60 mmol) of Meldrum's acid and 25 mg (0.22 mmol) of D,L-proline were added to a solution of 0.95 g (4.38 mmol) of the compound from Example 11A in 36 ml of acetonitrile. The reaction mixture was stirred at RT overnight. It was concentrated to result in 3.10 g (97% of theory) of the title compound with a purity of 68% which were reacted without further purification.

후처리

  1. concentrationIt was concentrated

출처 및 근거

ORD 기록
ord-0062b61931c24b918ff9b8e86099ed4c
출처 데이터셋
uspto-grants-2011_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08063234B2

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