Azobisisobutyronitrile → 2-(Bromomethyl)-1-chloro-4-(2-methoxyethoxy)benzene

HRID 561794노트

반응식

HRID 561794 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][O:11][CH3:12])=[CH:4][C:3]=1[CH3:13].[Br:14]N1C(=O)CCC1=O.CC(N=NC(C#N)(C)C)(C#N)C>C(Cl)(Cl)(Cl)Cl>[Br:14][CH2:13][C:3]1[CH:4]=[C:5]([O:8][CH2:9][CH2:10][O:11][CH3:12])[CH:6]=[CH:7][C:2]=1[Cl:1]

참가 물질

5

반응물 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 22467254HCID 22467254, 화합물

생성물 1

HCID 591775552-(Bromomethyl)-1-chloro-4-(2-methoxyethoxy)benzene

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

To a solution of 1-chloro-4-(2-methoxyethoxy)-2-methylbenzene from the previous step (1 eq.) in carbon tetrachloride (0.02 M) was added N-bromosuccinimide (1 eq.) and a few crystals of AIBN (1.1 eq.). The resulting mixture was irradiated with sunlamp at reflux for 1 h. The insolubles were removed via filtration and the filtrate was concentrated in vacuo to furnish the title compound.

후처리

  1. customThe resulting mixture was irradiated with sunlamp
  2. temperatureat reflux for 1 h
  3. customThe insolubles were removed via filtration
  4. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-5e9a531dabde4f8f95c5003ed456e315
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063105B2

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