Acetic Acid → 2-(3-Fluorophenyl)oxirane
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[CH2:6].C(O)(=[O:12])C.BrN1C(=O)CCC1=O.[OH-].[Na+]>O1CCOCC1.O>[F:1][C:2]1[CH:3]=[C:4]([CH:5]2[CH2:6][O:12]2)[CH:7]=[CH:8][CH:9]=1참가 물질
7
실험 절차
To a solution of m-fluorostyrene (5.00 g, 41.0 mmol) and acetic acid (2.33 mL, 40.9 mmol) in dioxane (33 ml) and H2O (78 ml) at 0° C. was added N-bromosuccinimide (8.02 g, 45.0 mmol) in three portions. The reaction was allowed to warm to RT. After 4 hours, 2N NaOH (60 ml) was added and the reaction was left to stir at RT overnight. The reaction mixture was partitioned between water and EtOAc, and the aqueous phase was extracted with EtOAc. The combined organic phases were washed with brine, dried (Na2SO4), filtered and evaporated in vacuo to give 6.30 g of the title compound as a slightly tinted oil which was used without further purification.
후처리
- waitthe reaction was left
- customThe reaction mixture was partitioned between water and EtOAc
- extractionthe aqueous phase was extracted with EtOAc
- washThe combined organic phases were washed with brine
- dry with materialdried (Na2SO4)
- filtrationfiltered
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-401201bccdab428d8118c9da64818ac2
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08067450B2
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