Ethyl benzoylacetate → Ethyl 2-benzoyl-3-ethoxyacrylate

HRID 563443

반응식

[O:1]=[C:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH:15](OCC)(OCC)[O:16][CH2:17][CH3:18].C(OC(=O)C)(=O)C>>[C:2]([C:3](=[CH:15][O:16][CH2:17][CH3:18])[C:4]([O:6][CH2:7][CH3:8])=[O:5])(=[O:1])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

반응물 3

HCID 7170Ethyl benzoylacetate

HCID 7918Acetic Anhydride

HCID 31214Ethyl orthoformate

생성물 1

HCID 98006Ethyl 2-benzoyl-3-ethoxyacrylate수율 59%

반응 조건

온도: 135 °C

실험 절차

A mixture of ethyl 3-oxo-3-phenylpropanoate (17.2 mL, 100 mmol), triethyl orthoformate (24.5 mL, 150 mmol), and acetic anhydride (38 mL, 400 mmol) was stirred at 135° C. for 5 hr. Distillation under reduced pressure gave ethyl 2-benzoyl-3-ethoxyacrylate (14.7 g, 59 mmol, 59% yield) as a yellow liquid.

후처리

distillationDistillation under reduced pressure

출처 및 근거

ORD 기록: ord-360ad2945a2d4e8abbaba90644bdd00b
출처 데이터셋: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08067447B2

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