Hydrogen Bromide → 3-Bromo-4-hydroxyphenylacetic acid

HRID 563530

반응식

HRID 563530 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8]C.Br>C(O)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[OH:8]

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 1366153-Bromo-4-methoxyphenylacetic acid

생성물 1

HCID 27696283-Bromo-4-hydroxyphenylacetic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

3-Bromo-4-methoxyphenylacetic acid (1.3 g, 5.6 mmol) was heated in a solution of hydrogen bromide (3 mL) and acetic acid (3 mL) at 100° C. overnight. The mixture was then partitioned between EtOAc and H2O, and the aqueous layer was separated and extracted with EtOAc. The combined organic layers were washed with brine, dried over MgSO4, filtered, and concentrated to give the title compound.

후처리

  1. customThe mixture was then partitioned between EtOAc and H2O
  2. customthe aqueous layer was separated
  3. extractionextracted with EtOAc
  4. washThe combined organic layers were washed with brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-aa313f2ce17b461c8e45403b4c2cb189
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067445B2

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