Phosgene → Carbamic chloride, N-ethyl-N-(phenylmethyl)-

HRID 563684

반응식

HRID 563684 반응식
[CH2:1]([NH:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:2].C(N(C(C)C)CC)(C)C.[C:20](Cl)([Cl:22])=[O:21]>C(Cl)Cl>[CH2:1]([N:3]([CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[C:20]([Cl:22])=[O:21])[CH3:2]

참가 물질

5

반응물 3

HCID 6371PhosgeneHCID 81531DiisopropylethylamineHCID 84352N-Ethylbenzylamine

생성물 1

HCID 10679448Carbamic chloride, N-ethyl-N-(phenylmethyl)-

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

N-Ethylbenzylamine (0.56 mL, 3.8 mmol) and diisopropylethylamine (1 mL, 5.7 mmol) were combined in CH2Cl2 (12 mL) and cooled to 0° C. Phosgene (20% in toluene; 2.4 mL, 4.6 mmol) was added, and the reaction was stirred overnight at room temperature. The mixture was concentrated, and the residue was dissolved in Et2O and washed twice with H2O. The organic layer was dried, filtered, and concentrated to give the title compound.

후처리

  1. concentrationThe mixture was concentrated
  2. dissolutionthe residue was dissolved in Et2O
  3. washwashed twice with H2O
  4. customThe organic layer was dried
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2fabad5641c5426cae656d4326331fa4
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067445B2

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