5-Bromo-2-fluorobenzaldehyde → (5-Bromo-2-fluorophenyl)methanol
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH:9]=1)[CH:7]=[O:8].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH2:7][OH:8])[CH:9]=1참가 물질
4
실험 절차
To a solution of 5-bromo-2-fluorobenzaldehyde (1.3 g, 6.4 mmol) in MeOH (10 mL) was added sodium borohydride (0.29 g, 7.7 mmol), and the reaction was stirred at room temperature for 5 minutes. After aqueous work-up, the residue was purified by silica gel chromatography to give the title compound.
후처리
- customAfter aqueous work-up, the residue was purified by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-e013470df19541eaa101c5ba8cb8d399
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08067445B2
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