Water → 1-Methyl-1H-indazol-5-ol

HRID 563893

반응식

HRID 563893 반응식
N[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[N:6]=[CH:5]2.[OH2:12].[OH-].[Na+]>P(=O)(O)(O)O>[OH:12][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[N:6]=[CH:5]2

참가 물질

5

반응물 3

HCID 962Water2회HCID 14798Sodium HydroxideHCID 27680321-methyl-1H-indazol-5-amine

생성물 1

HCID 441192401-Methyl-1H-indazol-5-ol

시약·촉매·용매 1

HCID 1004Phosphoric Acid용매

반응 조건

온도
180 °C

실험 절차

5-Amino-1-methylindazole (1.56 g) in phosphoric acid (13 ml) containing water (3 ml) was heated to 180° C. for 18 hours, cooled to ambient temperature, poured into water (5 ml) then neutralised with aqueous sodium hydroxide. The solid that precipitated was filtered from solution, washed with cold water then sucked to dryness to give was hydrolysed to give 5-hydroxyl-1-methylindazole as a brown solid, (1.18 g).

후처리

  1. temperaturecooled to ambient temperature
  2. customThe solid that precipitated
  3. filtrationwas filtered from solution
  4. washwashed with cold water
  5. customto give

출처 및 근거

ORD 기록
ord-00365a0cbbd14c7a905837875a647ed6
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067592B2

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