Dimethylformamide → 2-(3-Bromophenyl)-2-methylpropanenitrile

HRID 564015노트

반응식

HRID 564015 반응식
[H-].[Na+].[Br:3][C:4]1[CH:5]=[C:6]([CH2:10][C:11]#N)[CH:7]=[CH:8][CH:9]=1.I[CH3:14].C[N:16]([CH:18]=O)C>C(OCC)C>[Br:3][C:4]1[CH:5]=[C:6]([C:10]([CH3:11])([CH3:14])[C:18]#[N:16])[CH:7]=[CH:8][CH:9]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 36023(3-Bromophenyl)acetonitrile

생성물 1

HCID 105132942-(3-Bromophenyl)-2-methylpropanenitrile

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

257 mg 95% sodium hydride were stirred at room temperature in 25 ml dry DMF under an atmosphere of nitrogen. A solution of 1 g 3-bromophenylacetonitrile and 1.593 g iodomethane in 10 ml dry diethyl ether was added slowly below 30° C. The mixture was stirred over night at room temperature and then quenched by addition of a small amount of water. The solvents were evaporated under vacuum and the residue was purified by chromatography on silica in a heptane/ethyl acetate gradient.

후처리

  1. customquenched by addition of a small amount of water
  2. customThe solvents were evaporated under vacuum
  3. customthe residue was purified by chromatography on silica in a heptane/ethyl acetate gradient

출처 및 근거

ORD 기록
ord-06100fb05b61410ea109aedc47e1e36e
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067599B2

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