Sodium Hydroxide → 7-Chlorofuro[2,3-c]pyridine

HRID 564710노트

반응식

HRID 564710 반응식
[O:1]1[C:5]2[C:6](=O)[NH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1.CC1C=CC(COC(NNC(C2C=NC=CN=2)=O)=O)=CC=1.[OH-].[Na+].P(Cl)(Cl)([Cl:36])=O>>[Cl:36][C:6]1[N:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2][O:1][C:5]=12

참가 물질

5

반응물 4

HCID 14798Sodium HydroxideHCID 24813Phosphorus oxychlorideHCID 478568p-tolylmethyl N-(pyrazine-2-carbonylamino)carbamateHCID 12826106Furo[2,3-c]pyridine-7(6H)-one

생성물 1

HCID 128261077-Chlorofuro[2,3-c]pyridine

실험 절차

A solution of 6-H-furo[2,3-c]pyridin-7-one (1.0 g) in phosphorous oxychloride (10 ml) was stirred at 110° C. for 30 minutes under dry nitrogen. The mixture was cooled, poured onto ice/water (50 ml) and basified to pH10 with 2N sodium hydroxide solution. The mixture was extracted with ether (3×50 ml), the combined extracts dried over sodium sulfate and filtered. Removal of the solvent in vacuo gave the title compound (1.0 g) as a white solid.

후처리

  1. temperatureThe mixture was cooled
  2. additionpoured onto ice/water (50 ml)
  3. extractionThe mixture was extracted with ether (3×50 ml)
  4. dry with materialthe combined extracts dried over sodium sulfate
  5. filtrationfiltered
  6. customRemoval of the solvent in vacuo

출처 및 근거

ORD 기록
ord-bea149978ea74ce2bb63d0fde5e11375
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06169090A

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