3-Phenoxy-alpha-ethynylbenzylalcohol → HCID 86740322, 화합물

HRID 569530

반응식

HRID 569530 반응식
[CH3:1][C:2]1([CH3:16])[C@@H:4](/[CH:5]=[CH:6]\[C:7](=[O:12])[O:8][CH2:9][CH2:10][F:11])[C@H:3]1[C:13]([OH:15])=[O:14].[C:17]([CH:19](O)[C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:21]=1)#[CH:18]>C(Cl)(Cl)Cl>[CH3:1][C:2]1([CH3:16])[C@@H:4](/[CH:5]=[CH:6]\[C:7](=[O:12])[O:8][CH2:9][CH2:10][F:11])[C@H:3]1[C:13]([O:15][CH:19]([C:17]#[CH:18])[C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:21]=1)=[O:14]

참가 물질

4

반응물 2

HCID 129190923-Phenoxy-alpha-ethynylbenzylalcoholHCID 86740321HCID 86740321, 화합물

생성물 1

HCID 86740322HCID 86740322, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Using the procedure of Step F of Example 9, (1R,cis)2,2-dimethyl-3-[(Z)3-oxo-3-(2-fluoroethoxy)-1-propenyl]-cyclopropane-carboxylic acid and α-ethynyl-3-phenoxy-benzyl alcohol were reacted to obtain α-ethynyl-3-phenoxy-benzyl(1R,cis)2,2-dimethyl-3-[(Z)3-oxo-3-(2-fluoroethoxy)-1-propenyl]-cyclopropane-carboxylate with a specific rotation of [α]D20 =+47°±1.5° (c=1% in CHCl3).

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-cbca38010e6c43b1ab5197060e8151d1
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04732903

연결된 노트

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