Sodium Hydroxide → 2-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide

HRID 569811

반응식

HRID 569811 반응식
[Br:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([Br:16])=[CH:12][C:11]=2[F:17])=[O:7])=[C:4]([N+:20]([O-])=O)[CH:3]=1.[OH-].[Na+]>C(O)(=O)C.[Fe]>[NH2:20][C:4]1[CH:3]=[C:2]([Br:1])[CH:19]=[CH:18][C:5]=1[C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([Br:16])=[CH:12][C:11]=1[F:17])=[O:7]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 144589874-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide

생성물 1

HCID 144589952-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide수율 98%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매

반응 조건

온도
100 °C

실험 절차

A mixture of 4-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide (3.4 g) and iron (1.45 g) in acetic acid (66 ml) was stirred at 100° C. for 30 minutes. After cooling, iron was filtered off. The filtrate was evaporated to give a residue, which was made alkaline with aqueous 1N sodium hydroxide and extracted with ethyl acetate. The extract was washed with water and dried. Removal of the solvent gave 2-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide (3.10 g).

후처리

  1. temperatureAfter cooling
  2. filtrationiron was filtered off
  3. customThe filtrate was evaporated
  4. customto give a residue, which
  5. extractionextracted with ethyl acetate
  6. washThe extract was washed with water
  7. customdried
  8. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-6cdceda0523d43728be68130110121d7
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04734419

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