Hydrochloric Acid → N,N'-Bis[4-(chloromethyl)phenyl]-N,N'-dimethylurea

HRID 570028노트

반응식

HRID 570028 반응식
[CH3:1][N:2]([C:15]1[CH:20]=[CH:19][C:18](CO)=[CH:17][CH:16]=1)[C:3]([N:5]([CH3:14])[C:6]1[CH:11]=[CH:10][C:9]([CH2:12]O)=[CH:8][CH:7]=1)=[O:4].[ClH:23].CCCCCC.[CH:30]([Cl:33])(Cl)Cl>>[CH3:1][N:2]([C:15]1[CH:20]=[CH:19][C:18]([CH2:30][Cl:33])=[CH:17][CH:16]=1)[C:3]([N:5]([CH3:14])[C:6]1[CH:11]=[CH:10][C:9]([CH2:12][Cl:23])=[CH:8][CH:7]=1)=[O:4]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 6212ChloroformHCID 8058HexaneHCID 54431102HCID 54431102, 화합물

생성물 1

HCID 20064895N,N'-Bis[4-(chloromethyl)phenyl]-N,N'-dimethylurea

실험 절차

A solution of 10 g N,N'-dimethyl-N,N'-bis(p-hydroxymethylphenyl) urea in 250 ml CHCl3 was stirred vigorously for two hours with 250 ml conc. HCl. The layers were separated, and the organic phase was washed with dilute HCl, dried, and stripped to give a yellow oil. Trituration with hexane caused the product to crystallize. Filtration, washing with hexane, and air drying gave 3.5 g of a fluffy-white crystalline solid which was pure by TLC, m.p. 72°-73° C.

후처리

  1. customThe layers were separated
  2. washthe organic phase was washed with dilute HCl
  3. customdried
  4. customto give a yellow oil
  5. customto crystallize
  6. filtrationFiltration
  7. washwashing with hexane, and air
  8. customdrying

출처 및 근거

ORD 기록
ord-30702cb4383c4c449f2d0143ecfd9834
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04734458

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