Water → 1-(1-Isocyanoethanesulfonyl)-4-methylbenzene

HRID 570820노트

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HRID 570820 반응식
[C:1]1([CH3:13])[CH:6]=[CH:5][C:4]([S:7]([CH2:10][N+:11]#[C-:12])(=[O:9])=[O:8])=[CH:3][CH:2]=1.[CH3:14]I.[OH-].[Na+].O>ClCCl>[C:1]1([CH3:13])[CH:2]=[CH:3][C:4]([S:7]([CH:10]([N+:11]#[C-:12])[CH3:14])(=[O:8])=[O:9])=[CH:5][CH:6]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 161915Tosylmethyl isocyanide

생성물 1

HCID 110528851-(1-Isocyanoethanesulfonyl)-4-methylbenzene수율 99.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of toluene-4-sulfonylmethylisocyanide (15 g), methyl iodide (109 g) benzyl trimethyl ammonium chloride (3.5 g) in dichloromethane (300 mL) was added 5 mol/L aqueous sodium hydroxide solution (307 mL) under ice cooling, and this mixture was stirred at same temperature for 2 hours. To this reaction mixture was added water and this mixture was extracted with diethyl ether. This organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (16 g).

후처리

  1. extractionthis mixture was extracted with diethyl ether
  2. washThis organic layer was washed with water and brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-9ac30c72c78f4f89b5b995e75e743155
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09023882B2

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