Dimethyl Sulfoxide → HCID 59478041, 화합물

HRID 570821노트

반응식

HRID 570821 반응식
[H-].[Na+].C1(C)C=CC(S([CH:12]([N+:14]#[C-])C)(=O)=O)=CC=1.[C:17](#[N:24])[CH:18]=[CH:19][CH2:20][CH2:21][CH2:22][CH3:23].CS(C)=O.[CH2:29](OCC)[CH3:30]>O>[CH2:20]([C:19]1[C:18]([C:12]#[N:14])=[CH:17][NH:24][C:29]=1[CH3:30])[CH2:21][CH2:22][CH3:23]

참가 물질

7

반응물 5

HCID 679Dimethyl SulfoxideHCID 3283Diethyl Ether2회HCID 24758Sodium hydrideHCID 287344HCID 287344, 화합물HCID 110528851-(1-Isocyanoethanesulfonyl)-4-methylbenzene

생성물 1

HCID 59478041HCID 59478041, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a suspension of sodium hydride (60%, 0.096 g) in diethyl ether (3 mL) were added a solution of 1-(toluene-4-sulfonyl)ethylisocyanide (0.42 g) and 2-heptenenitrile (0.22 g) in a mixed solvent of diethyl ether (3 mL) and dimethylsulfoxide (3 mL) at room temperature, and this mixture was stirred at room temperature for 1 hour. To this reaction mixture was added water (15 mL). This mixture was extracted with ethyl acetate, and this organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: ethyl acetate/n-hexane) to give the title compound (0.19 g).

후처리

  1. extractionThis mixture was extracted with ethyl acetate
  2. washthis organic layer was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was removed under reduced pressure
  5. customThe residue was purified by column chromatography on silica gel (eluent: ethyl acetate/n-hexane)

출처 및 근거

ORD 기록
ord-82461a7798fd4b4a9a52befd31b019e3
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09023882B2

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