Sodium hydride → Methyl 2-(5,5-dimethyl-5'-nitro-2'-oxospiro[[1,3]dioxane-2,3'-indoline]-1'-yl)acetate

HRID 571226노트

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HRID 571226 반응식
[CH3:1][C:2]1([CH3:20])[CH2:19][O:18][C:5]2([C:13]3[C:8](=[CH:9][CH:10]=[C:11]([N+:14]([O-:16])=[O:15])[CH:12]=3)[NH:7][C:6]2=[O:17])[O:4][CH2:3]1.[H-].[Na+].Br[CH2:24][C:25]([O:27][CH3:28])=[O:26]>CN(C=O)C>[CH3:1][C:2]1([CH3:20])[CH2:3][O:4][C:5]2([C:13]3[C:8](=[CH:9][CH:10]=[C:11]([N+:14]([O-:16])=[O:15])[CH:12]=3)[N:7]([CH2:24][C:25]([O:27][CH3:28])=[O:26])[C:6]2=[O:17])[O:18][CH2:19]1

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 60984Methyl bromoacetateHCID 154073515',5'-Dimethyl-5-nitrospiro[indoline-3,2'-[1,3]dioxan]-2-one

생성물 1

HCID 86681647Methyl 2-(5,5-dimethyl-5'-nitro-2'-oxospiro[[1,3]dioxane-2,3'-indoline]-1'-yl)acetate수율 84%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
0 °C

실험 절차

Crude 5,5-dimethyl-5′-nitrospiro[[1,3]dioxane-2,3′-indolin]-2′-one (obtained as described in Example 17, Step 1) (361 mg) was dissolved in dry DMF (11 ml) and cooled to 0° C.; NaH (60% w/w dispersion in mineral oil, 83 mg, 2.076 mmol) was added; and the mixture was stirred at 0° C. for 10 minutes (the reaction turned dark orange). Methyl 2-bromoacetate (0.144 ml, 1.557 mmol) was then added, the reaction was warmed to room temperature and stirred for 3 hours. The solvent was evaporated, water was added and extracted with EtOAc; the combined organic layers were dried over Na2SO4, filtered and evaporated. The crude was purified by flash chromatography on silica gel cartridge (petroleum ether:EtOAc from 95:5 to 85:15) affording methyl 2-(5,5-dimethyl-5′-nitro-2′-oxospiro[[1,3]dioxane-2,3′-indoline]-1′-yl)acetate (344 mg, 0.982 mmol, 84% yield). MS/ESI+ 351.0 [MH]+.

후처리

  1. temperaturethe reaction was warmed to room temperature
  2. stirringstirred for 3 hours
  3. customThe solvent was evaporated
  4. additionwater was added
  5. extractionextracted with EtOAc
  6. dry with materialthe combined organic layers were dried over Na2SO4
  7. filtrationfiltered
  8. customevaporated
  9. customThe crude was purified by flash chromatography on silica gel cartridge (petroleum ether:EtOAc from 95:5 to 85:15)

출처 및 근거

ORD 기록
ord-157acb5f71bb4069870ac73177abad0e
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09024027B2

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