Hydrochloric Acid → 5-(2,2-Difluoroethoxy)-3-fluoro-pyridine-2-carboxylic acid
반응식
[OH-].[Na+].[F:3][CH:4]([F:19])[CH2:5][O:6][C:7]1[CH:8]=[C:9]([F:18])[C:10]([C:13]([O:15]CC)=[O:14])=[N:11][CH:12]=1.Cl.O1CCOCC1>C1COCC1>[F:19][CH:4]([F:3])[CH2:5][O:6][C:7]1[CH:8]=[C:9]([F:18])[C:10]([C:13]([OH:15])=[O:14])=[N:11][CH:12]=1참가 물질
6
실험 절차
Sodium hydroxide (2 M in water, 2.43 mL, 4.86 mmol) is added to a solution of ethyl 5-(2,2-difluoroethoxy)-3-fluoro-pyridine-2-carboxylate (242 mg, 0.97 mmol) in THF (10 mL). The reaction is stirred at room temperature for 5 days. The reaction is quenched by the addition of 4 M HCl in dioxane (1.25 mL, 5 mmol) and the solution is concentrated to give the crude title compound (493 mg, 229%). ES/MS (m/e): 222.0 (M+1).
후처리
- concentrationthe solution is concentrated
출처 및 근거
- ORD 기록
- ord-f612b36ab35a44d0a502314ac03ded05
- 출처 데이터셋
- uspto-grants-2015_05
- 특허 번호
- US09029367B2
반응 노트
불러오는 중…