Sodium Hydroxide → 2-(2-Chloropyridin-4-yl)-2,4-diazabicyclo[3.1.0]hexan-3-one

HRID 572422노트

반응식

HRID 572422 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[CH:13]3[CH:11]([CH2:12]3)[N:10](C(OCC3C=CC=CC=3)=O)[C:9]2=[O:24])[CH:5]=[CH:4][N:3]=1.[OH-].[Na+]>Cl>[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[C:9](=[O:24])[NH:10][CH:11]3[CH:13]2[CH2:12]3)[CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86729664Benzyl 4-(2-chloropyridin-4-yl)-3-oxo-2,4-diazabicyclo[3.1.0]hexane-2-carboxylate

생성물 1

HCID 867296652-(2-Chloropyridin-4-yl)-2,4-diazabicyclo[3.1.0]hexan-3-one수율 83%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of benzyl 4-(2-chloropyridin-4-yl)-3-oxo-2,4-diazabicyclo-[3.1.0]hexane-2-carboxylate (I-30b: 20.0 mg, 0.058 mmol) in 3.0 mL of 6N HCl was heated to 100° C. for 1 hour. The resulting mixture was basified with 1N NaOH. The reaction mixture was cooled and partitioned between ethyl acetate and water. The organic layer was concentrated and washed with hexane to afford 10 mg of the product (83% yield).

후처리

  1. temperatureThe reaction mixture was cooled
  2. custompartitioned between ethyl acetate and water
  3. concentrationThe organic layer was concentrated
  4. washwashed with hexane

출처 및 근거

ORD 기록
ord-6c8dc0decbcd4ca8b84e043e6063eb9d
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029399B2

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