Methyl iodide → HCID 178503348, 화합물

HRID 573293

반응식

HRID 573293 반응식
[NH:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]1[SH:10].CI.[C:13]([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH3:13][S:10][C:2]1[NH:3][C:4]2=[N:5][CH:6]=[CH:7][CH:8]=[C:9]2[N:1]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178527819HCID 178527819, 화합물

생성물 1

HCID 178503348HCID 178503348, 화합물수율 22%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 1H-imidazo[4,5-b]pyridine-2-thiol (5.0 g) in acetone (75 mL) were added MeI (2.3 mL) and K2CO3 (18 g) at room temperature. After stirring for 1 day, the mixture was filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to give the title compound (1.2 g).

후처리

  1. filtrationthe mixture was filtered
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography (AcOEt/hexane)

출처 및 근거

ORD 기록
ord-83f8525bd2344d57981d3734115d833a
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029536B2

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