Diisopropylethylamine → HCID 178463033, 화합물

HRID 573344노트

반응식

HRID 573344 반응식
[NH2:1][C:2]1[CH:3]=[N:4][N:5]([CH2:11][CH3:12])[C:6]=1[C:7]([O:9]C)=O.C(O)(=O)C.[CH:17](N)=[NH:18].CCN(C(C)C)C(C)C>C(O)CCC>[CH2:11]([N:5]1[C:6]2[C:7]([OH:9])=[N:18][CH:17]=[N:1][C:2]=2[CH:3]=[N:4]1)[CH3:12]

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 160693Formamidine acetateHCID 54775640Methyl 4-amino-1-ethyl-1H-pyrazole-5-carboxylate

생성물 1

HCID 178463033HCID 178463033, 화합물수율 86.6%

시약·촉매·용매 1

HCID 2631-Butanol용매

반응 조건

온도
120 °C

실험 절차

A mixture of methyl 4-amino-1-ethyl-1H-pyrazole-5-carboxylate (1.75 g), formamidine acetate (1.615 g), n-butanol (20 mL) and DIPEA (20 mL) was stirred at 120° C. for 3 h. The mixture was concentrated under reduced pressure, and the residual crystals were washed with AcOEt/hexane to give the title compound (1.47 g).

후처리

  1. concentrationThe mixture was concentrated under reduced pressure
  2. washthe residual crystals were washed with AcOEt/hexane

출처 및 근거

ORD 기록
ord-281c048aa3bc4786a9fa55ad353ca83f
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029536B2

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