Hydrochloric Acid → 3-Amino-5,6-bis(trifluoromethyl)pyrazine-2-carbohydrazide

HRID 574241노트

반응식

HRID 574241 반응식
[NH2:1][C:2]1[C:3]([C:16](OCC)=[O:17])=[N:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1.O.[NH2:22][NH2:23].Cl>CO.O>[NH2:1][C:2]1[C:3]([C:16]([NH:22][NH2:23])=[O:17])=[N:4][C:5]([C:12]([F:14])([F:15])[F:13])=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 24654Hydrazine hydrate (1:1)HCID 86657667Ethyl 3-amino-5,6-bis(trifluoromethyl)pyrazine-2-carboxylate

생성물 1

HCID 867296083-Amino-5,6-bis(trifluoromethyl)pyrazine-2-carbohydrazide

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A suspension of ethyl 3-amino-5,6-bis(trifluoromethyl)pyrazine-2-carboxylate (Int. G1)(455 mg, 1.501 mmol) in MeOH (10 ml) was treated with hydrazine monohydrate (0.147 ml, 3.00 mmol) and stirred at RT overnight. The reaction mixture was diluted with water (50 ml) and the pH was adjusted to pH4-5 using 1M HCl. A yellow precipitate formed which was filtered under vacuum, washed with water and air dried to afford the title compound which was used without further purification;

후처리

  1. customA yellow precipitate formed which
  2. filtrationwas filtered under vacuum
  3. washwashed with water and air
  4. customdried

출처 및 근거

ORD 기록
ord-4b9721b5aba7433ebc7a754459f50caa
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034879B2

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