Diisopropylethylamine → HCID 178499453, 화합물

HRID 576659노트

반응식

HRID 576659 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][N+:3]=1[O-:13].CCN(C(C)C)C(C)C.[NH2:23][CH2:24][CH2:25][NH:26][C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30]>CC(O)(C)C>[C:29]([O:28][C:27]([NH:26][CH2:25][CH2:24][NH:23][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][N+:3]=1[O-:13])=[O:33])([CH3:32])([CH3:31])[CH3:30]

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 187201N-BOC-ethylenediamineHCID 59464117HCID 59464117, 화합물

생성물 1

HCID 178499453HCID 178499453, 화합물수율 32.2%

시약·촉매·용매 1

HCID 6386tert-Butanol용매

반응 조건

온도
80 °C

실험 절차

To 2-chloro-5-(2-methoxy-2-oxoethyl)pyridine 1-oxide (2.5 g) in t-BuOH (50 mL) was added DIEA (3.4 mL) and tert-butyl 2-aminoethylcarbamate (3.0 g). The resulting reaction mixture was stirred at 80° C. for 2 days. The solvent was then removed and the residue purified by reverse phase chromatography to afford the desired product (1.3 g).

후처리

  1. customThe resulting reaction mixture
  2. customThe solvent was then removed
  3. customthe residue purified by reverse phase chromatography

출처 및 근거

ORD 기록
ord-9492210acb694b7d8711dd1f333c4dae
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040504B2

반응 노트

불러오는 중…