Phosphorus tribromide → 2-(Bromomethyl)-1-methyl-1H-benzimidazole hydrobromide

HRID 576993

반응식

HRID 576993 반응식
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:11]O.P(Br)(Br)[Br:14]>ClCCl>[BrH:14].[Br:14][CH2:11][C:3]1[N:2]([CH3:1])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=1

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 344177(1-methyl-1H-1,3-benzodiazol-2-yl)methanol

생성물 1

HCID 242294512-(Bromomethyl)-1-methyl-1H-benzimidazole hydrobromide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (1-methyl-1H-benzimidazol-2-yl)methanol (1.1 g, 6.8 mmol) in anhydrous dichloromethane (60 mL) was added dropwise phosphorus tribromide (1.3 mL, 14.0 mmol). The mixture was stirred at room temperature overnight. Dichloromethane was evaporated. The residue was dried in vacuo, affording 2-(bromomethyl)-1-methyl-1H-benzimidazole hydrobromide. The product was used without further purification.

후처리

  1. customDichloromethane was evaporated
  2. customThe residue was dried in vacuo

출처 및 근거

ORD 기록
ord-57f3301b836a4bb08298525512a33331
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040538B2

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