Phosphorus tribromide → 4-(Bromomethyl)-3-chloro-5-ethylpyridine

HRID 577099노트

반응식

HRID 577099 반응식
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH2:10][CH3:11])[C:7]=1[CH2:8]O.[Br:12]P(Br)Br>C(Cl)(Cl)Cl>[Br:12][CH2:8][C:7]1[C:6]([CH2:10][CH3:11])=[CH:5][N:4]=[CH:3][C:2]=1[Cl:1]

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 59589363(3-Chloro-5-ethylpyridin-4-yl)methanol

생성물 1

HCID 595893674-(Bromomethyl)-3-chloro-5-ethylpyridine

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a solution of (3-chloro-5-ethylpyridin-4-yl)methanol (1.83 g, 10.66 mmol) in anhydrous chloroform (40 mL) was added dropwise tribromophosphane (2.91 g, 1.01 mL, 10.75 mmol) at 0° C. The reaction mixture was allowed to stir overnight at room temperature. The solvent was evaporated to provide crude 4-(bromomethyl)-3-chloro-5-ethylpyridine, which was used in the next step without further purification.

후처리

  1. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-10fcb7616fd54e6c9cef20513f230a60
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040538B2

반응 노트

불러오는 중…