2-Tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole → 6-Amino-2-tert-butyl-5-(4-methylpiperazin-1-yl)benzothiazole

HRID 5790

반응식

HRID 5790 반응식
[C:1]([C:5]1[S:6][C:7]2[CH:13]=[C:12]([N+:14]([O-])=O)[C:11]([N:17]3[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]3)=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Ni]>[NH2:14][C:12]1[C:11]([N:17]2[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]2)=[CH:10][C:8]2[N:9]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[S:6][C:7]=2[CH:13]=1

참가 물질

4

반응물 1

HCID 197942002-Tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole

생성물 1

HCID 197941766-Amino-2-tert-butyl-5-(4-methylpiperazin-1-yl)benzothiazole

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

A solution of 86 g of the above nitro compound in 150 ml of ethanol is hydrogenated in presence of 30 g of Raney nickel at 45°. The solution is filtered to give 6-amino-2-tert-butyl-5-(4-methylpiperazin-1-yl)benzothiazole, melting at 130° C.

후처리

  1. filtrationThe solution is filtered

출처 및 근거

ORD 기록
ord-c4b9469cd7684e858e4abf2ec83970cc
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05246927

연결된 노트

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