Potassium Carbonate → methyl 2-(5-bromo-2-oxopyridin-1(2H)-yl)acetate
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.Br[CH2:10][C:11]([O:13][CH3:14])=[O:12].C([O-])([O-])=O.[K+].[K+]>CS(C)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[N:6]([CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH:7]=1참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
To solution of 5-bromopyridin-2(1H)-one (2.5 g, 14.37 mmol) and methyl 2-bromoacetate (2.418 g, 15.81 mmol) in DMSO (12 mL) was added K2CO3 (2.383 g, 17.24 mmol). The mixture was stirred at 60° C. for 4 hours, filtered, and purified via preparative HPLC, eluting with a gradient of 10-90% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA) to give the title compound.
후처리
- filtrationfiltered
- custompurified via preparative HPLC
- washeluting with a gradient of 10-90% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA)
출처 및 근거
- ORD 기록
- ord-8a9a13226ab74f98ba60f664d65d6a8f
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434743B2
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