Methyl iodide → 5-Bromo-1,4-dimethyl-1,2-dihydropyridin-2-one
반응식
[Br:1][C:2]1[C:3]([CH3:9])=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.IC.[C:12](=O)([O-])[O-].[K+].[K+]>CS(C)=O>[Br:1][C:2]1[C:3]([CH3:9])=[CH:4][C:5](=[O:8])[N:6]([CH3:12])[CH:7]=1참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
To a solution of 5-bromo-4-methylpyridin-2(1H)-one (164 mg, 0.872 mmol) and iodomethane (124 mg, 0.872 mmol) in DMSO (3 mL) was added potassium carbonate (121 mg, 0.872 mmol). The mixture was stirred at 60° C. overnight, filtered, and purified via preparative HPLC, eluting with a gradient of 20-70% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA) to give the title compound.
후처리
- filtrationfiltered
- custompurified via preparative HPLC
- washeluting with a gradient of 20-70% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA)
출처 및 근거
- ORD 기록
- ord-fe8fd08f64a148a9b12e5008fd63ca04
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434743B2
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