Hydrochloric Acid → HCID 10488443, 화합물
반응식
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[C:14]([O:16]C)=[O:15])[NH:10][CH:9]=[CH:8]2)=[O:4].C(O)C.[OH-].[Na+].Cl>O>[NH:10]1[C:11]2[C:7](=[CH:6][C:5]([C:3]([OH:4])=[O:2])=[C:13]([C:14]([OH:16])=[O:15])[CH:12]=2)[CH:8]=[CH:9]1참가 물질
6
실험 절차
To a stirred solution of the dimethyl ester produced in step d (1.14 g, 4.9 mmol) in a 5:1 mixture of ethanol:water (12 ml) was added solid sodium hydroxide (0.49 g, 12.4 mmol). The solution was stirred at a gentle reflux for 3 h. The solution was acidifed on cooling to pH2 with hydrochloric acid and then evaporated. The residue was azeotroped with ethanol and then toluene and dried under vacuum. The residue was then extracted with hot acetone (5×20 ml) and the combined extracts were evaporated to leave the title compound (870 mg).
후처리
- temperaturea gentle reflux for 3 h
- customevaporated
- customThe residue was azeotroped with ethanol
- dry with materialtoluene and dried under vacuum
- extractionThe residue was then extracted with hot acetone (5×20 ml)
- customthe combined extracts were evaporated
출처 및 근거
- ORD 기록
- ord-d6d7975f136e47188961638934aa813d
- 출처 데이터셋
- uspto-grants-1999_07
- 특허 번호
- US05919829
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