Benzene, 2-fluoro-4-methyl-1-nitro- → [2-(3-Fluoro-4-nitro-phenyl)-vinyl]-dimethyl-amine

HRID 58170

반응식

HRID 58170 반응식
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>CN(C=O)C>[F:1][C:2]1[CH:7]=[C:6]([CH:8]=[CH:14][N:15]([CH3:17])[CH3:16])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

참가 물질

4

반응물 2

HCID 67966Benzene, 2-fluoro-4-methyl-1-nitro-HCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 91252016[2-(3-Fluoro-4-nitro-phenyl)-vinyl]-dimethyl-amine수율 63%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
125 °C

실험 절차

A mixture of 2-fluoro-4-methyl-1-nitro-benzene (3 g, 19.3 mmol), N,N-dimethylformamide dimethylacetal (10 mL) and 3 mL of DMF (30 mL) was heated at 125° C. for 1 hour. The mixture was cooled and concentrated under reduced pressure to give a purple solid. Trituration with hexanes gave the pure title product (2.5 g, yield: 63%). MS (ESI): 211 [M+H]+.

후처리

  1. temperatureThe mixture was cooled
  2. concentrationconcentrated under reduced pressure
  3. customto give a purple solid

출처 및 근거

ORD 기록
ord-817877ea94764f208294308ee7121a8b
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434697B2

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