Hydrochloric Acid → 2-Oxobicyclo(3.1.0)hexane-6-carboxylic acid

HRID 582850

반응식

HRID 582850 반응식
[O:1]=[C:2]1[CH2:7][CH2:6][CH:5]2[CH:3]1[CH:4]2[C:8]([O:10]CC)=[O:9].Cl>[OH-].[Na+]>[O:1]=[C:2]1[CH2:7][CH2:6][CH:5]2[CH:3]1[CH:4]2[C:8]([OH:10])=[O:9]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 565357Ethyl 2-oxobicyclo[3.1.0]hexane-6-carboxylate

생성물 1

HCID 102194732-Oxobicyclo(3.1.0)hexane-6-carboxylic acid

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

반응 조건

온도
27.5 °C

실험 절차

A mixture of 60 g of ethyl 2-oxobicyclo[3.1.0]hexane-6-carboxylate and 300 ml of 1N sodium hydroxide was stirred at 25-30° C. After 2.5 hours, concentrated hydrochloric acid was added to adjust the pH to 0.8-1.2. The resulting solution was extracted with ethyl acetate. The extracts were dried over magnesium sulfate, filtered, and concentrated to give 49.1 g (98%) of the crude material. Recrystallization from 100 ml of ethyl acetate gave the title compound, mp 123.5-128° C.

후처리

  1. extractionThe resulting solution was extracted with ethyl acetate
  2. dry with materialThe extracts were dried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customto give 49.1 g (98%) of the crude material
  6. customRecrystallization from 100 ml of ethyl acetate

출처 및 근거

ORD 기록
ord-8eb0ecb922d641a1b4197c564caa7971
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05925782

연결된 노트

불러오는 중…