Hydrochloric Acid → 5-(3-Bromophenyl)-1H-1,2,4-triazole

HRID 586314

반응식

HRID 586314 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12](COCC[Si](C)(C)C)[N:11]=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:12][N:11]=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22329519HCID 22329519, 화합물

생성물 1

HCID 124615465-(3-Bromophenyl)-1H-1,2,4-triazole수율 89.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

This reaction was carried out as described in Example 40, step b, using 5-(3-bromophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-[1,2,4]triazole (2.88 g, 8.1 mmol), 2 N HCl (50 ml) and ethanol (50 ml) to yield the title compound (1.62 g, 89%): 1H NMR (360 MHz, DMSO-d6) δ 8.70 (1H, s), 8.16 (1H, s), 8.01 (1H, d, J 7.8 Hz), 7.63 (1H, d, J 7.8 Hz), 7.46 (1H, t, J 7.8 Hz).

출처 및 근거

ORD 기록
ord-ed683daacb8b4ec984001d9b2ef31b96
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06936608B2

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