N-bromobutanimide → Ethyl 3-(4-bromo-3-hydroxyphenyl)propanoate
반응식
[CH2:1]([O:3][C:4](=[O:14])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([OH:13])[CH:8]=1)[CH3:2].[Br:15]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:14])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([Br:15])=[C:9]([OH:13])[CH:8]=1)[CH3:2]참가 물질
4
실험 절차
To a −10° C. solution of 3-(3-hydroxy-phenyl)-propionic acid ethyl ester (2.0 g, 10.31 mmol) in chloroform (0.2 M, 51 mL) was added N-bromosuccinimide (1.93 g, 10.83 mmol). After stirring at RT overnight, the solution was concentrated in vacuo and purified by flash column chromatography (SiO2, 5% to 15% ethyl acetate/hexanes) to give the product as a colorless oil (0.45 g, 16%).
후처리
- concentrationthe solution was concentrated in vacuo
- custompurified by flash column chromatography (SiO2, 5% to 15% ethyl acetate/hexanes)
출처 및 근거
- ORD 기록
- ord-cc04f682fdd0450685eac8a69a26e2d5
- 출처 데이터셋
- uspto-grants-2016_01
- 특허 번호
- US09227914B2
반응 노트
불러오는 중…