Water → (R)-4-benzyl-3-((S)-tetrahydrofuran-3-carbonyl)oxazolidin-2-one

HRID 58881

반응식

HRID 58881 반응식
C(N=C=NCCCN(C)C)C.[CH2:12]([C@@H:19]1[CH2:23][O:22][C:21](=[O:24])[NH:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[O:25]1[CH2:29][CH2:28][CH:27]([C:30](O)=[O:31])[CH2:26]1.O>CN(C1C=CN=CC=1)C.C(Cl)Cl>[CH2:12]([C@@H:19]1[CH2:23][O:22][C:21](=[O:24])[N:20]1[C:30]([C@H:27]1[CH2:28][CH2:29][O:25][CH2:26]1)=[O:31])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

7

반응물 4

HCID 962WaterHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 2734969(R)-4-Benzyl-2-oxazolidinoneHCID 4661317(R)-Tetrahydro-3-furoic acid

생성물 1

HCID 67314494(R)-4-benzyl-3-((S)-tetrahydrofuran-3-carbonyl)oxazolidin-2-one수율 25.6%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDCI; 362 mg, 1.90 mmol) and DMAP (202 mg, 1.90 mmol) were added to a solution of (R)-4-benzyl-oxazolidin-2-one (333 mg, 1.90 mmol) and tetrahydrofuran-3-carboxylic acid (200 mg, 1.70 mmol) in CH2Cl2 (20 mL) at ambient temperature. The reaction mixture was stirred for 3 h at ambient temperature and water (20 mL) was added. The two layers were separated and the aqueous phase was extracted with CH2Cl2 (20 mL×3). The combined organic phases were washed with brine (50 mL×3), dried over anhydrous sodium sulfate and concentrated. The residue was purified by flash column chromatography on silica gel (CH2Cl2/EtOAc=100:2) to afford (R)-4-benzyl-3-((S)-tetrahydrofuran-3-carbonyl)oxazolidin-2-one (120 mg, 25% yield).

후처리

  1. customThe two layers were separated
  2. extractionthe aqueous phase was extracted with CH2Cl2 (20 mL×3)
  3. washThe combined organic phases were washed with brine (50 mL×3)
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated
  6. customThe residue was purified by flash column chromatography on silica gel (CH2Cl2/EtOAc=100:2)

출처 및 근거

ORD 기록
ord-4630c42d87374dfda80d82eef65a9dbc
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434761B2

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