Hydrochloric Acid → 2-[3-[4-(4-chlorobenzamido)benzyl]-1H-indazol-1-yl]acetic acid

HRID 589360노트

반응식

HRID 589360 반응식
[Cl:1][C:2]1[CH:32]=[CH:31][C:5]([C:6]([NH:8][C:9]2[CH:30]=[CH:29][C:12]([CH2:13][C:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[N:16]([CH2:23][C:24]([O:26]CC)=[O:25])[N:15]=3)=[CH:11][CH:10]=2)=[O:7])=[CH:4][CH:3]=1.CO.O.[OH-].[Li+].Cl>O1CCCC1.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C:9]2[CH:30]=[CH:29][C:12]([CH2:13][C:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[N:16]([CH2:23][C:24]([OH:26])=[O:25])[N:15]=3)=[CH:11][CH:10]=2)=[O:7])=[CH:31][CH:32]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 168937Lithium hydroxide, monohydrateHCID 89590282ethyl 2-[3-[4-(4-chlorobenzamido)benzyl]-1H-indazol-1-yl]acetate

생성물 1

HCID 715718292-[3-[4-(4-chlorobenzamido)benzyl]-1H-indazol-1-yl]acetic acid수율 74.9%

시약·촉매·용매 2

HCID 962Water용매2회HCID 8028Tetrahydrofuran용매

실험 절차

Ethyl 2-[3-[4-(4-chlorobenzamido)benzyl]-1H-indazol-1-yl]acetate (100 mg, 0.223 mmol) was dissolved in 3 mL tetrahydrofuran, and 1 mL methanol, 3 mL water were added. In an ice bath was, 47 mg (1.12 mmol) lithium hydroxide monohydrate was added. I was moved to be at room temperature and reacted for 10 minutes. The reaction was monitored to be complete by TLC. Diluted hydrochloric acid was added to adjust pH to be acidic. Water was added, pumping filtered, dried to obtain a white solid 70 mg, at a yield of 74.9%

후처리

  1. customIn an ice bath was
  2. customto be at room temperature
  3. customreacted for 10 minutes
  4. filtrationpumping filtered
  5. customdried

출처 및 근거

ORD 기록
ord-c24f70785ba045d1acc62f7efbece5b4
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233098B2

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