Hydrochloric Acid → 2-[1-[4-(2-naphthamido)benzyl]-1H-indazol-3-yl]acetic acid

HRID 589367노트

반응식

HRID 589367 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([NH:13][C:14]1[CH:35]=[CH:34][C:17]([CH2:18][N:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:21]([CH2:28][C:29]([O:31]CC)=[O:30])=[N:20]2)=[CH:16][CH:15]=1)=[O:12].O.[OH-].[Li+].O.Cl>O1CCCC1>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([NH:13][C:14]1[CH:15]=[CH:16][C:17]([CH2:18][N:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:21]([CH2:28][C:29]([OH:31])=[O:30])=[N:20]2)=[CH:34][CH:35]=1)=[O:12]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 90449170ethyl 2-[1-[4-(2-naphthamido)benzyl]-1H-indazol-3-yl]acetate

생성물 1

HCID 715568942-[1-[4-(2-naphthamido)benzyl]-1H-indazol-3-yl]acetic acid수율 58%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Ethyl 2-[1-[4-(2-naphthamido)benzyl]-1H-indazol-3-yl]acetate (226 mg, 0.488 mmol) was dissolved in tetrahydrofuran (10 mL), and in an ice bath 10 mL aqueous solution of lithium hydroxide monohydrate (62 mg, 1.48 mmol) was added. It was reacted at room temperature for 3 h, and the reaction was monitored to be complete by TLC. Water was added into the system, and adjusted to pH≈3-4 with diluted hydrochloric acid. A solid precipitated. It was filtered, and dried to obtain a white solid 123 mg, at a yield of 58%.

후처리

  1. customIt was reacted at room temperature for 3 h
  2. customA solid precipitated
  3. filtrationIt was filtered
  4. customdried

출처 및 근거

ORD 기록
ord-d18a1ceefe2849e8b030f2d3b8184a59
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233098B2

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