Cyclohexylamine → HCID 42614802, 화합물

HRID 59014

반응식

HRID 59014 반응식
Br[CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[CH2:3]1.[CH:12]1([NH2:18])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>C1C=CC=CC=1>[CH:12]1([NH:18][CH:2]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[C:4](=[O:11])[CH2:3]2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

참가 물질

4

반응물 2

HCID 7965Cyclohexylamine2회HCID 117459123-Bromo-1-indanone

생성물 1

HCID 42614802HCID 42614802, 화합물수율 84%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

3-Bromo-2,3-dihydro-1H-inden-1-one (100 mg, 475 μmol) and cyclohexylamine (94 mg, 951 μmol) were dissolved in 2 mL of dry benzene and stirred under N2 until precipitation ceased (˜15 min) The cyclohexylamine.HBr was removed by filtration. The filtrate was applied to a flash SiO2 column that was developed with 8:1 hexanes-EtOAc to give the title compound as a clear oil (91 mg, 84% yield).

후처리

  1. custom(˜15 min)
  2. customHBr was removed by filtration

출처 및 근거

ORD 기록
ord-53548c7e825e4ed685f012ad3877349d
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09439877B2

연결된 노트

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