홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → (6-((1,3-Dimethyl-1H-pyrazol-5-yl)methoxy)-4-methyl-1-benzothiophen-3-yl)acetic acid

HRID 591397
노트
인쇄 미리보기

반응식

HRID 591397 반응식
C[O:2][C:3](=[O:24])[CH2:4][C:5]1[C:9]2[C:10]([CH3:23])=[CH:11][C:12]([O:14][CH2:15][C:16]3[N:20]([CH3:21])[N:19]=[C:18]([CH3:22])[CH:17]=3)=[CH:13][C:8]=2[S:7][CH:6]=1.[OH-].[Na+].Cl>CCO>[CH3:21][N:20]1[C:16]([CH2:15][O:14][C:12]2[CH:11]=[C:10]([CH3:23])[C:9]3[C:5]([CH2:4][C:3]([OH:24])=[O:2])=[CH:6][S:7][C:8]=3[CH:13]=2)=[CH:17][C:18]([CH3:22])=[N:19]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 118667002Methyl(6-((1,3-dimethyl-1H-pyrazol-5-yl)methoxy)-4-methyl-1-benzothiophen-3-yl)acetate

생성물 1

HCID 89768917(6-((1,3-Dimethyl-1H-pyrazol-5-yl)methoxy)-4-methyl-1-benzothiophen-3-yl)acetic acid수율 79.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a mixture of methyl(6-((1,3-dimethyl-1H-pyrazol-5-yl)methoxy)-4-methyl-1-benzothiophen-3-yl)acetate (143 mg) and EtOH (2 mL) was added 1N NaOH (0.42 mL) at room temperature, and the mixture was refluxed for 30 min. The mixture was neutralized with 1N HCl at room temperature and extracted with EtOAc. The organic layer was separated, washed with brine, dried over MgSO4 and concentrated in vacuo. The residual solid was crystallized from EtOAc-hexane to give the title compound (109 mg).

후처리

  1. temperaturethe mixture was refluxed for 30 min
  2. extractionextracted with EtOAc
  3. customThe organic layer was separated
  4. washwashed with brine
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated in vacuo
  7. customThe residual solid was crystallized from EtOAc-hexane

출처 및 근거

ORD 기록
ord-9344cfa701e44ca588adc7afe2c440fe
출처 데이터셋
uspto-grants-2016_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09238639B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트