Hydrochloric Acid → 2-(3-Formylphenoxy)acetic acid
반응식
[CH:1]([C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][CH:15]=1)[O:6][CH2:7][C:8]([O:10]CC)=[O:9])=[O:2].[OH-].[Na+].Cl>CO>[CH:1]([C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][CH:15]=1)[O:6][CH2:7][C:8]([OH:10])=[O:9])=[O:2]참가 물질
5
실험 절차
ethyl 2-(3-formylphenoxy)acetate (47)/(1 eq) was taken in MeOH and cooled to 0° C. when NaOH (2 eq) solution was added drop wise. After completion of addition the reaction mixture was stirred at rt for 30 min. The reaction mixture was cooled to rt and acidified with dil HCl to attain pH 3 when a precipitate appeared which was filtered and washed well with water and dried well to yield a white solid (49%). NMR: δ 4.754 (s, 1H), 7.23-7.27 (m, 1H), 7.349 (s, 1H), 7.449 (d, J=4.8 Hz, 2H), 9.938 (s, 1H), 13.07 (s, 1H).
후처리
- additionwas added drop wise
- additionAfter completion of addition the reaction mixture
- temperatureThe reaction mixture was cooled to rt
- filtrationwas filtered
- washwashed well with water
- customdried well
출처 및 근거
- ORD 기록
- ord-b522a77d248e4268900a203f34313901
- 출처 데이터셋
- uspto-grants-2016_01
- 특허 번호
- US09238656B2
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